
The second season of the American television medical drama Grey's Anatomy commenced airing on the American Broadcasting Company on September 25, 2005, and concluded on May 15, 2006. The season was produced by Touchstone Television, in association with Shondaland production company and The Mark Gordon Company, the showrunner being Shonda Rhimes. Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, and T.R. Knight reprised their roles as surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley, respectively. Previous main cast members Chandra Wilson, James Pickens, Jr., Isaiah Washington, and Patrick Dempsey also returned, while Kate Walsh, who began the season in a recurring capacity, was promoted to series regular status, after appearing in seven episodes as a guest star. The season continued to focus on the surgical residency of five young interns as they try to balance to the challenges of their competitive careers, with the difficulties that determine their personal lives. It was set in the fictional Seattle Grace Hospital, located in the city of Seattle, Washington. Whereas the first season put the emphasis mainly on the unexpected impact the surgical field has on the main characters, the second one provides a detailed perspective on the personal background of each character, focusing on the consequences that their decisions have on their careers. Throughout the season, new story lines were introduced, including the love triangle between Meredith Grey, Derek Shepherd, and Addison Montgomery, the main arc of the season. Also heavily developed was the story line involving Izzie Stevens' relationship with patient Denny Duquette, which resulted in critical acclaim and positive fan response.
Name | Grey's Anatomy Season 2 |
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Air Date | September 25th, 2005 |
Genre | Drama |
Network | ABC |
Production Companies | The Mark Gordon Company, ShondaLand, ABC Studios, Touchstone Television |
Number of Episodes | 27 Episodes |
Plot Keywords | seattle, trauma, workplace, hospital, doctor, medical student, surgical interns, medical drama |









Episodes List
Grey's Anatomy Season 2 Episode 1 : Raindrops Keep Falling On My Head
September 25th, 2005Picks up where the last episode left off. Meredith attempts to work with Addison Shepard. George is pimped out to relay the hospital gossip back to We...
Grey's Anatomy Season 2 Episode 2 : Enough is Enough (No More Tears)
October 2nd, 2005There's tension between Meredith and Addison. We find out why Derek and Addison aren't together. Bailey puts George on an impossible case. The rest of...
Grey's Anatomy Season 2 Episode 3 : Make Me Lose Control
October 9th, 2005Cristina and Meredith try to figure out if Cristina should tell Burke that she's pregnant right before Cristina faces an emergency. Alex and Izzie get...
Grey's Anatomy Season 2 Episode 4 : Deny, Deny, Deny
October 16th, 2005As Cristina tries to recover, she proves to be a very difficult patient, and a visit from her mother doesn't improve her demeanor any. And Meredith's ...
Grey's Anatomy Season 2 Episode 5 : Bring the Pain
October 23rd, 2005Cristina goes right back to working right after being discharged. Izzie isn't talking to Alex. Derek and Meredith treat a patient. George and Alex get...
Grey's Anatomy Season 2 Episode 6 : Into You Like a Train
October 30th, 2005Train Wreck victims come to Seattle Grace and all staff gets called in. Everyone deals with really weird cases. Except Addison and Izzie. They work wi...
Grey's Anatomy Season 2 Episode 7 : Something to Talk About
November 6th, 2005Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane's case induces a spreading fascin...
Grey's Anatomy Season 2 Episode 8 : Let It Be
November 13th, 2005Meredith tries to avoid the Shepherds. Cristina and Burke go out on a date and end up getting caught up in their jobs. Derek asks Meredith not to igno...
Grey's Anatomy Season 2 Episode 9 : Thanks for the Memories
November 20th, 2005It's Thanksgiving at Seattle Grace Hospital but the holiday's festivites are less than in order. Meredith and Derek try to counsel a family after thei...
Grey's Anatomy Season 2 Episode 10 : Much Too Much
November 27th, 2005Dorie Russell is waiting for quintuplets, all 5 girls. Her husband seems more concerned than she is but she is set to bring her babies to their term o...
Grey's Anatomy Season 2 Episode 11 : Owner of a Lonely Heart
December 4th, 2005Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get...
Grey's Anatomy Season 2 Episode 12 : Grandma Got Run Over By a Reindeer
December 11th, 2005The holiday season has started but not everyone is in a festive mood. This is Alex's last day in the hospital unless he passes his boards practical ex...
Grey's Anatomy Season 2 Episode 13 : Begin the Begin
January 15th, 2006Cristina is bothered by a new year's mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. a heart transplant, 2. Izzie. Addison d...
Grey's Anatomy Season 2 Episode 14 : Tell Me Sweet Little Lies
January 22nd, 2006Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively. George is given a hard task t...
Grey's Anatomy Season 2 Episode 15 : Break on Through
January 29th, 2006All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally...
Grey's Anatomy Season 2 Episode 16 : It's the End of the World
February 5th, 2006An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a "Code Black" f...
Grey's Anatomy Season 2 Episode 17 : As We Know It
February 12th, 2006Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dea...
Grey's Anatomy Season 2 Episode 18 : Yesterday
February 19th, 2006Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a ...
Grey's Anatomy Season 2 Episode 19 : What Have I Done to Deserve This?
February 26th, 2006Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up. Derek and Addi...
Grey's Anatomy Season 2 Episode 20 : Band-Aid Covers the Bullet Hole
March 12th, 2006The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are ...
Grey's Anatomy Season 2 Episode 21 : Superstition
March 19th, 2006After a series of deaths at the hospital some of the staff become very superstitious. Izzie worries about Denny and gets confronted by Alex. A patien...
Grey's Anatomy Season 2 Episode 22 : The Name of the Game
April 2nd, 2006Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew's surgery bec...
Grey's Anatomy Season 2 Episode 23 : Blues for Sister Someone
April 30th, 2006Addison's patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient's husband won't use contraceptives. Derek tre...
Grey's Anatomy Season 2 Episode 24 : Damage Case
May 7th, 2006The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that ...
Grey's Anatomy Season 2 Episode 25 : 17 Seconds
May 14th, 2006George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie. A 12-week pregnant girl dies in the O.R. and h...
Grey's Anatomy Season 2 Episode 26 : Deterioration of the Fight or Flight Response
May 15th, 2006Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who ...
Grey's Anatomy Season 2 Episode 27 : Losing My Religion
May 15th, 2006This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member's condition. Callie ...